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Saban Oezipek

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Articles

The Power of Trypsin Immobilized Enzyme Reactors (IMERs) Deployed in Online MDLC–MS Applications

The Power of Trypsin Immobilized Enzyme Reactors (IMERs) Deployed in Online MDLC–MS Applications

Sina Hoelterhoff;Ingrid Grunert;Katrin Heinrich;Saban Oezipek;Martin Winter;Anja Bathke
April 1st 2022

Commercially available trypsin IMERs can digest proteins with high sequence coverage and robustness, facilitating online multidimensional LC–MS.

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Figure 1: Seven prioritization strategies in non-target screening (NTS) by chromatography–HRMS, grouped by domain: chemical information (P1–P3), toxicological information (P5–P6), external information (P4), and preprocessing (P2, P7). Each strategy narrows the candidate space based on specific criteria. Combined, they reduce complexity and focus identification on environmentally relevant features.
Published: May 19th 2025 | Updated: May 23rd 2025
HPLC 2025 Preview: Prioritization Strategies in Non-Target Screening of Environmental Samples by Chromatography with High-Resolution Mass Spectrometry
Nathalie Delaunay, Audrey Combès, and Valérie Pichon © Images courtesy of authors.
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HPLC 2025 Preview: Functionalized Monoliths as Selective Sample Preparation Materials
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