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Thomas Van Doninck

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Articles by Thomas Van Doninck

Antibodies, immunoglobulin Ig proteins 3D medical background. Immune system, IgM, IgG, IgE, IgD, IgA antibodies glycoproteins, specific antigens against coronavirus sars-cov-2 covid-19 influenza virus | Image Credit: © Corona Borealis - stock.adobe.com

MHC-Associated Peptide Proteomics (MAPPs) as a Tool for Assessment of Immunogenicity Risk Potential of Therapeutic Monoclonal Antibodies

ByThomas Van Doninck,Lauren Thijs,Chloé Ackaert,Kurt Boonen,Aurélie Mazy,Sofie Pattyn,Elise Pepermans
August 17th 2025

In this study, we applied a high-sensitivity MAPPs workflow using magnetic bead-based HLA-DR/DP/DQ immunoprecipitation and high-resolution mass spectrometry (HRMS) to assess the immunogenicity risk of six marketed mAbs across a panel of 10 HLA-typed donors.

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Latest Updated Articles

  • Antibodies, immunoglobulin Ig proteins 3D medical background. Immune system, IgM, IgG, IgE, IgD, IgA antibodies glycoproteins, specific antigens against coronavirus sars-cov-2 covid-19 influenza virus | Image Credit: © Corona Borealis - stock.adobe.com
    MHC-Associated Peptide Proteomics (MAPPs) as a Tool for Assessment of Immunogenicity Risk Potential of Therapeutic Monoclonal Antibodies

    August 17th 2025



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