The Application Notebook-02-01-2010

Genotoxic impurities in pharmaceutical products have come under increasing regulatory scrutiny, with exposure limits <1.5 μg/day typically being reported for most products.

In this study, data was collected to evaluate carryover of target analytes in subsequent blanks following high concentration samples.

The procedure involves a rapid and efficient pretreatment with SampliQ QuEChERS kits. The homogenized liver sample was initially extracted in a buffered aqueous/1% acetic acid acetonitrile system with an extraction and partitioning step after the addition of salts.

Recent technological advances in macromolecular crystallography led to focus on the study of more and more sophisticated biological systems, such as protein-protein complexes.

The procedure involves a rapid and efficient pretreatment by SampliQ QuEChERS kits. The homogenized liver sample was initially extracted in a buffered aqueous, 5% formic acid acetonitrile system.

Greater peak capacity and resolution can be easily obtained for gradient analysis of complex samples by using sub-2 µm particles in longer column lengths.

The GC–MS analysis of volatile organics in drinking water according to United States Environmental Protection Agency (US EPA) Method 524.2 offers a number of analytical challenges, ranging from water handling to very low target compound concentrations.

Excellent reversed-phase separations using a protein-based column, CHIRAL-AGP, with volatile LC–MS compatible buffer systems have been obtained for a range of basic solutes.