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News|Videos|October 14, 2026
Conversations with Michael Dong: Buffers for Mobile Phase A in Pharmaceutical Analysis
Author(s)Michael W. Dong
In this fourth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.
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Michael Dong, editor of LCGC International's "Perspectives in HPLC" column, has launched a video series in 2026 called "HPLC in Pharmaceutical Analysis," which explores how the technique is used in the pharmaceutical field.
In celebration of National Chemistry Week at the end of October, ChromatographyOnline.com is pleased to share "Conversations with Michael Dong" this month, featuring highlights from the series. We encourage readers to watch the full series, a free and thorough educational introduction to HPLC for pharmaceutical laboratory professionals at every stage of their careers who want to brush up on the basics. No matter how much experience you have with the technique, you're sure to come away with useful tips for sharpening your skills.
In this installment, Dong explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.
The entire video, “Why don’t you ‘always’ need buffers in HPLC?” can be accessed at
Previous videos in this series can be accessed here:
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