The Column-04-11-2017

Separating and quantifying both volatile and nonvolatile compounds in complex mixtures is a costly and time-consuming process presenting significant technical challenges. Fabrice Gritti from the Instrument, Core Research, Fundamental Group at Waters Corporation discusses his team’s unique solution to this problem, combining high-vacuum technology and low-density fluid chromatography (LDFC) with carbon dioxide as a mobile phase for a rapid and complete baseline separation of both volatile and nonvolatile compounds on a single instrument, single column, and a single run without the associated loss of resolution.

Researchers from the Medical University of Bialystok, Poland, have used metabolomics and liquid chromatography quadrupole time‑of‑flight mass spectrometry (LC–QTOF‑MS) to study human ocular fluids.

Incognito offers his advice on how to be a leader rather than a manager.

Waters Corporation has announced the opening of a new Solution Centre in Petaling Jaya, Selangor, Malaysia. The new facility is designed to advance liquid chromatography and mass spectrometry analytical capabilities, developing new applications and offering training to scientists within its demonstration and training facilities.

Researchers from the University of Chemistry and Technology in Prague, Czech Republic, have developed a saffron authentication process based on ultrahigh-performance liquid chromatography coupled to high resolution tandem mass spectrometry (UHPLC–HRMS/MS) and multivariate data analysis.

Shimadzu Corporation has opened a new European Innovation Center in Duisburg, Germany. The new facility will merge Shimadzu’s state-of-the-art analytical technologies with prominent topics, market expertise, and scientific research guided by some key opinion leaders.

Reach Separations is celebrating its 5th anniversary with a record year of growth.

Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard method to separate samples by molecular size. In protein analysis, size-exclusion chromatography is either applied to detect and quantify aggregation, or to measure the complete molar mass distribution. However, method development is not trivial and the choice of suitable detection options is crucial.

This article describes the evolution of traditional solid-phase extraction (SPE) into new techniques that are customized to the characteristics of specific matrices, including the removal of β-glucuronidase from urine samples and the removal of phospholipids and proteins from plasma samples.

The 41st International Symposium on Capillary Chromatography (ISCC) and the 14th GC×GC Symposium will be held in Fort Worth, Texas, USA, on the 14–19 May 2017. This preview offers a flavour of what to expect.

Click the title above to open The Column April 11, 2017 Europe & Asia issue, Volume 13, Number 5, in an interactive PDF format.

Click the title above to open The Column April 11, 2017 North American issue, Volume 13, Number 5, in an interactive PDF format.

Ellutia Chromatography Solutions has opened a new state‑of‑the-art facility in Ely, Cambridgeshire, UK, consolidating Ellutia’s offices, laboratories, production, and warehouse on one 15,000 sq. ft. site.