The Column-11-16-2011

The Column

Drug Discovery Advances Inextricably Linked to Specialty Gases

November 16, 2011

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The development and commercialisation of new medical drugs is a complex and costly process, but increasing pressure is being placed on drug companies to accelerate the timeline from discovery of new drugs, through to clinical trials and then to their release onto the market. The pharmaceutical industry continues to demand ever more advanced products aimed at improving health and the quality of modern-day life.

Tips for Achieving Consistent Performance and Long Life of UHPLC Columns when Using Water-Acetonitrile Gradients with Water Soluble Buffers

November 16, 2011

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Reversed-phase ultra high performance liquid chromatography (RP-UHPLC) columns are the most widely used UHPLC columns in analytical separations. As with other reversed-phase columns, analytes are separated in RP-UHPLC columns due to their differences in the degree of hydrophobic interaction with the stationary phase.

Flow splitting to improve peak capacity in on-line LC×LC

November 16, 2011

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The use of flow splitters between the two dimensions in on-line comprehensive two-dimensional liquid chromatography (LC×LC) has received little attention in comparison to their use in two dimensional gas chromatography.

Bird-brained molecular sexing

November 16, 2011

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A recent study on the evolution of avian sex chromosomes has focused on retroposons as a novel method for reconstructing gametologous gene trees.

Perfecting Processes in Drug Discovery

November 16, 2011

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Janet Kelsey of The Column spoke to Frédéric Cheviron, Sales & Marketing Manager for Chiral Technologies Europe, about the technology they use in drug development and how companies can improve their method development.