LCGC Asia Pacific-09-01-2019

LCGC Asia Pacific

LCGC Asia Pacific August/September 2019 Regular Issue PDF

September 01, 2019

Issue PDF



Click the title above to open the LCGC Asia Pacific August/September 2019 regular issue, Vol 22, No 3, in an interactive PDF format.

Strategies for the Quantification of Endogenously Present Small Molecules in Biological Samples

July 01, 2019

Pharmaceutical Perspectives



The main objective of this review article is to provide a clear summary of the different methods that can be used to quantify endogenous small molecules. Because of the increased use of mass spectrometry (MS) in the field of bioanalysis, a special focus will be placed on quantification by liquid chromatography (LC)–MS. Practical recommendations to face this bioanalytical challenge, in particular in terms of method validation, will also be provided.

GC×GC–TOF-MS and Comprehensive Fingerprinting of Volatiles in Food: Capturing the Signature of Quality

May 01, 2019




Chemical fingerprinting can provide evidence for quality differences resulting from botanical and geographical origins of primary food ingredients, post-harvest practices, production processes (such as traditional versus industrial processes), and the shelf-life evolution of finished products. This article discusses the strategic role and potential of comprehensive two-dimensional gas chromatography (GC×GC) combined with time-of-flight mass spectrometry (TOF-MS) and pattern recognition using template matching for data processing to unravel the quality traits of high-quality food products. Practical examples dealing with high-quality cocoa and extra-virgin olive oil are described.