LCGC Europe-04-01-2020

LCGC Europe sponsored the 2020 HTC Innovation Award to highlight innovation in separation science. The winner, Ryan Kelly, from Brigham Young University, in Utah, USA, has introduced an impressive array of innovative approaches to advance proteomics research using nano-liquid chromatography–mass spectrometry (nano‑LC–MS), LC–MS, and two‑dimensional (2D)-LC–MS, including the development and application of nanodroplet processing in one pot for trace samples (nanoPOTS). This platform, when combined with nano-LC–MS/MS, can identify more than 3000 protein groups in 10 cells, a greater level of proteome coverage than was previously possible for samples containing 5000 cells.

How can I use the hydrophobic subtraction model of reversed-phase selectivity to help me in method development? A recent Pittcon symposium discussed the history and practical use of the model, as well as insights into recent research that may enable expanded use of the model in the future.

This instalment describes newly introduced high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products at Pittcon 2020 and the year prior, and summarizes significant features and user benefits.

Our annual review of new liquid chromatography (LC) columns and accessories, introduced at Pittcon and other events.

This critical review describes recent applications and instrumental trends in comprehensive two-dimensional gas chromatography (GC×GC), with particular (though not exclusive) attention to the period 2018–2019 and that the concept of GC×GC is inherently simple. The maturity of GC×GC and future developments are also discussed.