LCGC Europe-05-01-2014

Part 2 of our yearly report on new products introduced at Pittcon. This instalment of "Column Watch" covers GC columns, SFC columns, and products for sample preparation including small benchtop instruments.

This month's "LC Troubleshooting" instalment looks at two reader-submitted questions regarding method calibration.

Event News

In this study, the quality-by-design principle is applied instead of trial-and-error in the development of a liquid chromatography (LC) method. A mixture of an active pharmaceutical ingredient and its 13 impurities was analyzed on a short narrow-bore column (50 mm ? 2.1 mm, packed with sub-2-?m particles) providing short analysis times. The performance of commercial modelling software for robustness testing was systematically compared to experimental measurements and design-of-experiment–based predictions.

John Hinshaw presents his annual review of GC instruments and accessories that were newly on display at Pittcon in March 2014, or were introduced to the marketplace in the preceding year.

A multi-residue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma. The method has been successfully applied to the analysis of 500 samples from pregnant women in a clinical study.

Click the title above to open the LCGC Europe May 2014 regular issue, Vol 27 No 5, in an interactive PDF format.