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LCGC Europe-05-01-2014

LCGC Europe

Quality by Design in Pharmaceutical Analysis Using Computer Simulation with UHPLC

May 01, 2014

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In this study, the quality-by-design principle is applied instead of trial-and-error in the development of a liquid chromatography (LC) method. A mixture of an active pharmaceutical ingredient and its 13 impurities was analyzed on a short narrow-bore column (50 mm ? 2.1 mm, packed with sub-2-?m particles) providing short analysis times. The performance of commercial modelling software for robustness testing was systematically compared to experimental measurements and design-of-experiment–based predictions.

Simultaneous Determination of Methylxanthines and Cotinine in Human Plasma by Solid-Phase Extraction Followed by LC–MS–MS

May 01, 2014

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A multi-residue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma. The method has been successfully applied to the analysis of 500 samples from pregnant women in a clinical study.

Vol 27 No 5 LCGC Europe May 2014 Regular Issue PDF

May 01, 2014

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Click the title above to open the LCGC Europe May 2014 regular issue, Vol 27 No 5, in an interactive PDF format.