LCGC North America-04-01-2007

LC-MS-MS has become a widely used technique for the fast and sensitive quantitation of small molecules. In this article, this approach has been extended to high-throughput quantitative LC-MS-MS analysis under GLP applications for a drug candidate in development from preclinical animal studies through clinical development.

LCGC North America

Today's laboratories are sophisticated, generate large amounts of data, and rely on electronic data collection and tracking via a laboratory information management system (LIMS).

LCGC North America
LC Troubleshooting

April 01, 2007

Prompted by a recently reviewed manuscript and a question from a reader, John Dolan examines the variability of retention times observed in LC methods in this month's installment of "LC Troubleshooting."

LCGC North America
MS - The Practical Art

April 01, 2007

In this month's "MS-The Practical Art," Michael Balogh takes a closer look at insight provided by Chuck McEwen regarding obstacles while using solvents.

Guest columnist Volker Schurig discusses the achievements of Emanuel Gil-Av in introducing enantioselectivity into chromatographic analysis.

LCGC North America

This month's installment of "Column Watch" is the conclusion of a two-part series in which columnist Ron Majors examines trends in column and sample prep introductions at Pittcon 2007.

Departments
LCGC North America

April 01, 2007

The Gold Editors' Choice Awards was presented to Waters Corporation (Waltham, Massachusetts) for the Synapt HD–MS system at Pittcon 2007 in Chicago, Illinois. Silver Awards were presented to Paraytec (York, United Kingdom) for the ActiPix and Thermo Fisher Scientific (San Jose, California) for the LTQ ETD system. Bronze Awards were presented to Bruker Optics (Billerica, Massachusetts) for the ALPHA FT-IR system and Horiba Jobin Yvon (Edison, New Jersey) for the Activa system.