LCGC North America-09-01-2013

The American Chemical Society (ACS) has named Daniel W. Armstrong, professor of chemistry and biochemistry at the University of Texas (UT) Arlington, to its 2013 Class of Fellows.

This troubleshooting study of a problem of retention time variation provides a good example of how to track down the source of a problem and how to speculate on probable cause.

A method using HR-MS systems to characterize the structures of metabolites is presented. The result is a general workflow for metabolism studies in drug discovery and development.

The establishment of a system suitability plan that focuses on the maintenance of the most important variable in any chiral separation screen - the column - is presented.

Ion chromatography (IC) is a similar technique to HPLC except that the detector of choice is usually a conductivity detector. IC is well suited for the analysis of a variety of inorganic and organic anions and cations.

When transferring HPLC methods between instruments, many parameters need to be considered. Knowledge of underlying principles and a few key equations will help you.

A review of the advances and trends in technology and applications discussed at the HPLC 2013 conference, including a summary of the awards presented.

Click the title above to open the LCGC North America September 2013 regular issue, Vol 31 No 9, in an interactive PDF format.