Special Issues-03-02-2018

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Liquid Chromatography Tandem Mass Spectrometry Method for Novel Psychoactive Substances: Kratom and Synthetic Cathinones in Urine

Debashish Roy;Christa L. Colyer;Allyson L. Mellinger;Erin C. Strickland;Gregory L. McIntire;Oneka T. Cummings

March 2nd 2018

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A novel “dilute-and-shoot” LC–MS/MS method is described for the analysis of “bath salts” sold as “legal” highs, including mitragynine and nine synthetic cathinones, in urine.

Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive Analyses

Sarah Trimpin;Ellen D. Inutan;Anil K. Meher;Santosh Karki;Sara Madarshahian;Madeline A. Fenner;Darrell D. Marshall;Charles N. McEwen

March 2nd 2018

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Novel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.

Rapid Online Reduction and Characterization of Protein Modifications Using Fully Automated Two-Dimensional High Performance Liquid Chromatography–Mass Spectrometry

Anja Bathke;Christian Bell;Christoph Gstöttner;Denis Klemm;Robert Kopf

March 2nd 2018

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A fully automated process for online peak fractionation and reduction of therapeutic antibodies with subsequent QTOF-MS characterization is presented. The technique is based on state-of-the-art 2D-HPLC technology coupled with additional HPLC modules via a dedicated software macro.