Charles N. McEwen | Authors
Articles
Combining Novel and Traditional Ionization Methods for Mass Spectrometry for More Comprehensive Analyses
Novel ionization processes provide gas-phase ions of a wide variety of materials using MS. These simple and sensitive methods operate from solution or a solid matrix. Both manual and automated platforms are described that allow rapid switching between the ionization methods of MAI, SAI, vSAI, and conventional ESI.
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical Analyses
A newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit Drugs
Experiments presented here demonstrate the suitability of LC–SAI-MS for the detection and quantification of pharmaceuticals, with limits of detection in the low parts-per-trillion range. A comparison of LC–ESI-MS to LC–SAI-MS also yielded favorable results for SAI.
Nonconventional Alternatives to LC–MS
An important attribute of a novel ionization process for use in mass spectrometry (MS) is its simplicity and flexibility to be hyphenated to conventional liquid-based separation methods.