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Special Issues-06-02-2019 | LCGC Supplements
Special Issues
Vol 36 No s6 HPLC and UHPLC June 2019 Special Issue
June 01, 2019
Special Issues June 2019
37
6
Click the title above to open the Recent Developments in HPLC and UHPLC 2019 special issue in an interactive PDF format.
Recycle Reversed-Phase Liquid Chromatography (LC) to Achieve Separations Based on One H/D Substitution on Aromatic Hydrocarbons
June 01, 2019
Articles
37
6
Ultrahigh efficiency separations based on the presence of one deuterium in benzene, toluene, and naphthalene were achieved by recycle chromatography using C18 silica columns. The discrimination mechanism of H/D isotopic species is discussed based on the dispersion interactions of a CH/CD group of the solute with the stationary phase as well as the mobile phase.
Progress in Peak Processing
June 01, 2019
Articles
37
6
The advantages and limitations of several recently introduced mathematical procedures for enhancing peak resolution in liquid chromatography (LC) are described. Despite advanced separation technologies and extensive knowledge in method development, peak overlap is still commonly observed. This article gives a brief overview of the advantages and limitations of recently introduced mathematical procedures for enhancing resolution.
Optimizing MS-Compatible Mobile Phases for IEX Separation of Monoclonal Antibodies
June 01, 2019
Articles
37
6
The impact of ionic strength, buffer capacity, and pH-response on the retention behavior and peak shape of mAb species characterization is evaluated for IEX-MS. The aim of the present study was to understand the impact of ionic strength, buffer capacity, and pH-response on the retention behavior and peak shape of mAb species.
A Look at Vacuum-Jacketed Columns: Maximum Efficiency, Easy Deployment Without Oven, and Improved LC–MS Performance
May 01, 2019
Articles
37
6
The design of a user-friendly vacuum-jacketed column (VJC) is described for improved LC–MS performance, which does not require a large vacuum chamber with multiple vacuum pumps. Using this configuration, the experimental peak capacities measured for a 2.1 mm × 100 mm column packed with sub-2-μm particles and placed in the VJC-MS probe are doubled with respect to standard LC–MS systems.