News|Articles|February 21, 2024
Analysis of N-Nitrosodimethylamine (NDMA) Impurity in Rantidine Products Using SIFT-MS
Author(s)Syft Technologies Inc
Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods. This application note describes the headspace-SIFT-MS analysis of ranitidine products which achieves a limit of quantitation of 2 ng g-1 for NDMA in 500 mg of drug product.
Newsletter
Join the global community of analytical scientists who trust LCGC for insights on the latest techniques, trends, and expert solutions in chromatography.
Trending on LCGC International
1
High-throughput Headspace Analysis of Volatile Nitrosamines and their Secondary Amine Precursors
2
GC-IMS Profiling of Flavor and Quality Changes in Cooked Crayfish
3
Detecting Estrogen Signatures in MCN Tumors via Targeted LC-MS/MS
4
Streamlined Method Development for Efficient and Reliable Lipid Nanoparticle Analysis
5
