News|Articles|August 2, 2023
ASMS 2023 HDX-MS with Inline Electrochemical Reduction of Disulfide Bonds: State-of-the-Art
Author(s)Antec
HDX-MS with online EC reduction enables successful epitope mapping of mAbs to challenging S-S bonded protein targets, e.g., VEGF. The biophysical characterization of VHH-IR4, a BBB-crossing single-domain antibody (sdAb) is described for the first time and was only possible using EC reduction.
Newsletter
Join the global community of analytical scientists who trust LCGC for insights on the latest techniques, trends, and expert solutions in chromatography.
Related Content
Trending on LCGC International
1
Thermo Fisher and NVIDIA Partner to Expand AI Driven Laboratory Automation
2
Waters Corporation Shareholders Approve Share Issuance for Planned Combination with BD Biosciences and Diagnostics
3
Layer-Resolved Corneal Proteomics Enabled by Laser Ablation Sampling and LC–MS/MS
4
Rapid Native HIC–MS Using Ammonium Tartrate for Robust Drug-to-Antibody Ratio Characterization of Antibody–Drug Conjugates
5