ASMS 2023 HDX-MS with Inline Electrochemical Reduction of Disulfide Bonds: State-of-the-Art

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HDX-MS with online EC reduction enables successful epitope mapping of mAbs to challenging S-S bonded protein targets, e.g., VEGF. The biophysical characterization of VHH-IR4, a BBB-crossing single-domain antibody (sdAb) is described for the first time and was only possible using EC reduction.