Development of a High-Throughput LC/MS/MS Assay for 13 Commonly Prescribed Pain Management Drugs from Urine with Cleanup Using Solid Phase Extraction (SPE)

Here is some of the most popular content posted on LCGC International this week.

Combining silicon micro-nanofabrication technology to create perfectly ordered separation beds on a silicon chip, i.e. micro-pillar array columns (µPACs) is a powerful innovation in liquid chromatography. This article discusses the numerous possibilities of micro-nanofabrication in the future of analytical chemistry in life science, covering sample preparation, separation science, and detection technologies.

The article discusses advancements in two-dimensional liquid and gas chromatography (LC×LC and GC×GC) to address the challenges of analyzing complex samples in non-target analysis.

In this study, an accurate, reliable analytical LC-MS/MS method for PFAS in water was developed to specifically quantify C1 to C4 PFAS in both potable and non-potable sources. A direct injection workflow was implemented to simplify the testing process and to avoid potential contamination originating from poor sample preparation procedures.