Dionex - Quantify Drug Metabolites with LC-MS-Charged Aerosol Detection

Here is some of the most popular content posted on LCGC International this week.

Combining silicon micro-nanofabrication technology to create perfectly ordered separation beds on a silicon chip, i.e. micro-pillar array columns (µPACs) is a powerful innovation in liquid chromatography. This article discusses the numerous possibilities of micro-nanofabrication in the future of analytical chemistry in life science, covering sample preparation, separation science, and detection technologies.

The article discusses advancements in two-dimensional liquid and gas chromatography (LC×LC and GC×GC) to address the challenges of analyzing complex samples in non-target analysis.

In this study, an accurate, reliable analytical LC-MS/MS method for PFAS in water was developed to specifically quantify C1 to C4 PFAS in both potable and non-potable sources. A direct injection workflow was implemented to simplify the testing process and to avoid potential contamination originating from poor sample preparation procedures.