Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation

Varian, Inc. has published an application note entitled Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation. Parabens are widely used as food additives, in personal care products and pharmaceutical formulations. They are relatively volatile but can easily be detected by the Varian ELSD. By manipulating the operating conditions, the Varian ELSD detects semi-volatile parabens, thus conserving sample integrity and providing maximum sensitivity. This application note shows that the innovative design of the Varian ELSD represents the next generation of ELSD technology, providing optimum performance across a diverse range of HPLC applications.