Cooking at high temperatures causes a chemical reaction between certain sugars and asparagine which causes acrylamide formation. In this technical note, we explore how to use Novum™ SLE tubes to clean up a coffee matrix in order to quantitate known acrylamide levels. The recovery is especially significant when you consider the polar nature of the acrylamide (LogP -0.27). In addition to high recoveries (>90 %), the low values for the standard deviation and %CV indicates method reproducibility.
New HPLC, MS, and CDS Products from 2024–2025: A Brief Review
June 5th 2025This review highlights the high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products that were introduced from 2024 to 2025, summarizing the technical specifications of each product and highlighting significant user benefits.
Extracting Oxygen Heterocyclic Compounds Using Deep Eutectic Solvents
June 2nd 2025Oxygen heterocyclic compounds are notable components in citrus-scented creams, though quality control is important when using these compounds. Researchers recently created a workflow for extracting these substances using a deep eutectic solvent (DES) for microwave-assisted extraction (MAE).
The LCGC Blog: A Simplified Guide for Weighted Fitting and its Significance in Separation Science
June 2nd 2025In this month's edition of the LCGC Blog, discover how weighted least squares regression enhances quantitation accuracy in analytical chemistry, particularly for low-concentration analytes in HPLC.
Quantifying Isavuconazole in Dried Blood Spots Using HPLC
May 21st 2025Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.
HPLC 2025 Preview: On The Road With Your Chromatograph?
Published: May 21st 2025 | Updated: May 21st 2025Brett Paull from the University of Tasmania, Tasmania and his team describe the latest development in portable LC instruments and their experience of taking portable systems out to the field.