Fast HPLC: Where Are We Four Years Later?

March 3, 2008

E-Separation Solutions

Four years ago, problems were slightly different for HPLC users. However, one main problem remains the same and will continue to remain the same.

Four years ago, problems were slightly different for HPLC users. However, one main problem remains the same and will continue to remain the same.

"Do things as quickly as possible and not spend a lot of money doing it," Todd D. Maloney of Eli Lilly and Company said. Maloney gave the first presentation during a technical session entitled "Fast HPLC: Where are we Four Years Later" on the second day of Pittcon 2008 in New Orleans

Maloney's talk, "Smaller Particles, Higher Pressures, and Faster Separations: The Current Status of Pharmaceutical Method Development Five Years Later," focused on practical considerations for implementing fast LC in various stages of drug development.

Michael McGinley and Jason Anspach of Phenomenex arranged the session to include a very diverse group according to McGinley. While focusing on the challenges that have faced thegroup, McGinley remained upbeat as to what lies ahead.

"It is an exciting time….The future looks bright."

Anspach later gave a presentation of his own on "Overcoming the Limitations of Sub 2 µm Materials in High Speed HPLC Methods."

Anspach's presentation listed some of the pros and cons to different commercially available materials in terms of not only efficiency, but also in terms of selectivity and their subsequent impact on the resolution

Presenters from Pfizer, Agilent Technologies, Eksigent, and Supelco rounded out the workshop.