The use of method development software with analytical quality by design (AQbD) approaches can produce robust methods but are limited by both access to the software and user proficiency. Other approaches require more manual intervention to select the correct conditions, interpret the results, and make decisions based on the data. This application note, we explore using a systematic screening protocol to develop a method for the analysis of a mixture of nine structurally similar spice cannabinoids.
High pH and Temperature with HALO® ELEVATE C18, 1.5 mm ID Column
December 11th 2024Over the course of 5000 injections, the HALO®Elevate C18 1.5 mm ID column demonstrates stability and robustness in the stationary phase and the column hardware, with no significant changes to the retention time, peak shape, and back pressure.
Separation of Antidepressants Using HALO 90 Å PCS C18 Compared to C18
December 11th 2024A mix of four antidepressants is separated using the HALO®PCS (positive charged surface) C18 column demonstating the improved tailing factor and efficiency when compared to a traditional (uncharged) C18 stationary phase.