Glycan characterization data analysis
Waters has announced that it has entered into an agreement with PREMIER Biosoft International to co-market software produced by the firm with their mass spectrometry solutions for glycan and glycopeptide analysis.
Waters has announced that it has entered into an agreement with PREMIER Biosoft International to co-market software produced by the firm with their mass spectrometry solutions for glycan and glycopeptide analysis. According to the company, by augmenting their separations science products, mass spectrometers and UPLC chemistries with the data analysis software, biopharmaceutical manufacturers can obtain business-critical information critical for understanding biotherapeutic stability and safety.
Glycans are branching polymeric sugar molecules attached to biopharmaceuticals following protein translation and the determination of the sites of glycan attachment and the population of glycans present are required for both therapeutic and safety assessments.
According to the company, its UPLC glycan solution provides high-resolving, reproducible and rapid methods to separate and detect a wide range of glycans. Additionally, when coupled with its mass spectrometers the solution provides additional structural confirmation of the glycans. The software is reported to predict the glycan structure on a protein molecule, score it and generate a list of probable glycans that closely match the given MS profile.
For more information on these products visit the companies’ websites at www.waters.com and www.premierbiosoft.com
Emerging Trends and Challenges in Detecting Residues and Contaminants in Food in the Exposome Era
June 18th 2025This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such as LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasised.
New Research Explores Role of Nucleotide Hydrophobicity in Oligonucleotide Separation
June 18th 2025Researchers from Waters and Biospring studied the contribution of nucleotide type and modifications on the retention and resolution of 22–24 nt long oligonucleotides in different chromatographic methods.
A Life Measured in Peaks: Honoring Alan George Marshall (1944–2025)
June 18th 2025A pioneer of FT-ICR Mass Spectrometry, Alan G. Marshall (1944–2025), is best known for co-inventing Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), a transformative technique that enabled ultrahigh-resolution analysis of complex mixtures. Over a career spanning more than five decades at institutions like the University of British Columbia, The Ohio State University, and Florida State University, he published over 650 peer-reviewed papers and mentored more than 150 scientists. Marshall’s work profoundly impacted fields ranging from astrobiology to petroleomics and earned him numerous prestigious awards and fellowships. Revered for his intellect, mentorship, and dedication to science, he leaves behind a legacy that continues to shape modern mass spectrometry.
