Guide to LC Troubleshooting

Achieve >99% spectral accuracy and sub-mDa precision on standard LC/MS systems. Learn how MassWorks™ enables confident formula ID—no high-resolution MS required.

In this study, an accurate, reliable analytical LC-MS/MS method for PFAS in water was developed to specifically quantify C1 to C4 PFAS in both potable and non-potable sources. A direct injection workflow was implemented to simplify the testing process and to avoid potential contamination originating from poor sample preparation procedures.

Dairy milk is one commodity that can be impacted by environmental contaminants, such as PFAS, so it is important to implement extensive, robust, and accurate testing. In this work, a sensitive and reliable method was developed for the analysis of PFAS in milk by LC-MS/MS at levels as low as 0.01 µg/kg.

The following PFAS method collection, organized by region, provides an overview of the scope of current PFAS testing methods and guidelines as well as the recommended products used for each.

Finding suitable columns and products for PFAS analysis can be simplified using the product guide tables below, which detail the lab supplies for PFAS analysis that are appropriate for widely accepted test methods from around the world, including U.S. agencies (CDC, EPA, FDA, and USDA); European agencies (DIN); and international standards (ASTM and ISO).

Check out this short video that explains the importance of delay columns in managing background PFAS contamination.