A High Sensitivity UPLC/MS/MS Method for the Analysis of Fluticasone Propionate in Plasma

This application note illustrates a high-sensitivity method for the analysis of fluticasone propionate in rat plasma using ACQUITY UPLC and Xevo TQ MS. High sensitivity was achieved using just 375 uL of plasma in a rapid-throughput assay. The rapid data capture of the Xevo TQ MS allowed for the narrow MRM peaks to be accurately defined and quantified.