High-Speed SFC Enantiomeric Separation Using the Optimal Daicel SFC Chiral Columns

Daicel Chiral Technologies' unique HPLC and SFC chiral stationary phases are capable of separating the most challenging compounds, like the atropisomers of Sotorasib.

Application note demonstrating the improved chiral separation of herbicide mecoprop by use of an immobilized column that allows usage of a wider range of solvents

This application note demonstrates how the use of DCM in particular had a dramatic effect on the separation and afforded conditions that could be further adapted to a preparative scale application.

Mirtazapine is an approved antidepressant, with other studies exploring its use to treat sleep apnea, substance abuse withdrawal symptoms, and as an antihistamine.

Monoclonal antibodies (mAbs) are effective therapeutics for cancers, auto-immune diseases, viral infections, and other diseases. Recent developments in antibody therapeutics aim to add more specific binding regions (bi- and multi-specificity) to increase their effectiveness and/or to downsize the molecule to the specific binding regions (for example, scFv or Fab fragment) to achieve better penetration of the tissue. As the molecule gets more complex, the possible high and low molecular weight (H/LMW) impurities become more complex, too. In order to accurately analyze the various species, more advanced detection than ultraviolet (UV) is required to characterize a mAb sample.

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.