High-Speed SFC Enantiomeric Separation Using the Optimal Daicel SFC Chiral Columns

Supercritical fluid chromatography (SFC) is an evolutionary technology and a powerful tool for enantiomer separation when used in combination with chiral stationary phases (CSPs).

In parallel to the recent advancements in SFC instruments, there has been significant evolution of chiral columns in terms of CSP enantioselectivity, versatility, column stability, and efficiency. In order to provide optimal SFC chiral columns for ultra-fast analysis, the product line of chiral columns based on polysaccharide derivatives has recently been extended to new column dimensions.

Figure 1: Examples of fast chiral analysis by SFC.

Experimental and Discussion

As shown in the separation examples, Daicel chiral columns packed with 3-µm CSP particles and sized to 3.0-mm i.d. × 100 mm long can take full advantage of state-of-the-art SFC instrumentation to achieve fast and ultra-fast chiral separations without compromising the optimal resolution of enantiomers. These beneficial properties can be attributed to the high enantiorecognition ability of the CSPs, van Deemter fast mass-transfer kinetics, column packing stability, and the selection of column diameter.

Chromatographic Conditions

CHIRALPAK is a registered trademark of Daicel Corporation

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