The separation of mixtures of polar and hydrophilic compounds can be a significant challenge.
The separation of mixtures of polar and hydrophilic compounds can be a significant challenge. Hydrophilic interaction liquid chromatography (HILIC) has proven to be a solid alternative for such applications. Its use has therefore increased rapidly during the last years and HILIC has become a cornerstone in many laboratories.
Adjustable Polyacrylamide Stationary Phases Enhance Separation Performance in Liquid Chromatography
June 12th 2023Adjustable polyacrylamide stationary phases developed by researchers enhance separation performance in liquid chromatography, according to a recent publication. The study demonstrates the synthesis of vinyl modified silica and the successful preparation of polyacrylamide modified silica (PAM-SIL) stationary phases, allowing for fine control of separation performance.
An Interview with AI About Its Potential Role in Separation Science
May 17th 2023We interviewed an AI program (ChatGPT) for LCGC North America asking questions about AI and its role in various applications for separation science to include data analysis, and high performance liquid chromatography (HPLC), hydrophilic-interaction chromatography (HILIC), reversed-phase liquid chromatography (RPLC), liquid chromatography–mass spectrometry (LC–MS), gas chromatography–mass spectrometry (GC–MS), high resolution mass spectrometry (HRIM–MS), high resolution tandem mass spectrometry (HRMS/MS), and related topics.
New Nickel Oxide Stationary Phase for Improved HILIC Separation
April 27th 2023A new study has reported the preparation, characterization, and chromatographic evaluation of a nickel oxide deposited silica stationary phase in HILIC, which exhibited multiple retention mechanisms and enhanced chromatographic selectivity for analytes.