HPLC Studies Relationship Between Preterm Infants and Intraventricular Hemorrhage

December 12, 2007

BMC Pediatrics reports on a study characterizing total homocysteine (tHcy) levels at birth in preterm and term infants and identifing associations with intraventricular hemorrhage (IVH) and other neonatal outcomes such as mortality, sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and thrombocytopenia.

BMC Pediatrics reports on a study characterizing total homocysteine (tHcy) levels at birth in preterm and term infants and identifing associations with intraventricular hemorrhage (IVH) and other neonatal outcomes such as mortality, sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and thrombocytopenia.

A group of 123 infants at less than 32 weeks gestation were compared to a group of 25 term infants. Two blood spots collected on filter paper with admission blood drawing were analyzed by HPLC. Statistical analysis included ANOVA, Spearman?s Rank Order Correlation and Mann-Whitney U test. Researchers found no association between IVH and tHcy. Male gender, prenatal steroids and preeclampsia were associated with differences in tHcy levels.