Introduction to Peptide Mapping

This week, LCGC International published a variety of articles on hot topics in separation science. Several analytical techniques were covered in these articles, including gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–MS (LC–MS).

To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was used to quantify antitumor prodrugs and their metabolites.

Using two-dimensional liquid chromatography–mass spectrometry, a new workflow was developed to characterize phosphorodiamidate morpholino oligomers, which can help treat infectious diseases.

To better detect polycyclic aromatic hydrocarbons in the human body, a UHPLC–MS/MS method was developed and tested on urine samples from workers exposed to diesel exhaust.

To quantify antibiotics in ICU patients’ blood, dried blood spot analysis was sued alongside UHPLC–MS/MS to monitor these substances in a more convenient matter.

In a new study, researchers used GC–MS and LC–MS were used to detect composition fraud in food supplement creation.