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Kromasil HILIC-D is designed for the best selectivity of polar compounds.
Kromasil HILIC-D is designed for the best selectivity of polar compounds. Kromasil HILIC-D offers a column that is 100% MS compatible. The phase is low bleed and the solvents used when running your HPLC in HILIC mode are optimal for MS. Therefore the sensitivity can be 100 times better when using Kromasil HILIC-D over traditional RP columns.
Traditionally, polar compounds like organic acids, nucleobases, and water soluble vitamins have been a challenge to separate on a standard reversed phase column like C18. Kromasil HILIC-D offers a phase that has true orthogonal selectivity when compared to a C18 column, normally giving an opposite elution order. The diol derivatized Kromasil HILIC-D provides excellent reproducibility when compared to HILIC columns based on standard bare silica.
When purifying polar compounds, Kromasil HILIC-D can be scaled up, offering the same great performance as in analytical scale. Take advantage of the generous surface area which can provide high loading capacity.