This symposium on drug discovery is organized by Sammy Datwani, and will be held in Room 117 from 1:30 to 4:45 pm.
This symposium on drug discovery is organized by Sammy Datwani, and will be held in Room 117 from 1:30 to 4:45 pm. In this symposium, recent advances of mass spectrometry (MS)–based label-free high-throughput screening techniques for drug discovery are discussed, with high specificity, high sensitivity, and high throughput similar to conventional plate-readers approaches based on spectroscopic technologies.
The first paper of the symposium is by Erin S Baker and James N Dodds of North Carolina State University. They present at 1:35 pm on “High Throughput Analysis in Drug Discovery: Utilizing Rapid Diagnostics with Ion Mobility-Mass Spectrometry.” This paper details the interface of high throughput sampling using a high-throughput MS system with a commercially available uniform field ion mobility-mass spectrometer for rapid diagnostic screening.
The second paper of this symposium is presented by Milan Mrksich of Northwestern University. The 2:10 pm paper is titled, “High Throughput Experiments with SAMDI Mass Spectrometry.” This talk describes the use of carbohydrate arrays to discover novel enzymes, the preparation of peptide arrays to profile the enzyme activities in cell lysates, and high-throughput screening to discover novel reactions and small molecular modulators.
The third symposium talk is entitled, “Application of Acoustic Mist Ionization Mass Spectrometry for Metabolic Profiling,” and is presented at 2:45 pm by Jonathan Wingfield of AstraZeneca. This paper details the use of acoustic mist ionization mass spectrometry (AMI-MS) hyphenated with a time of flight (TOF) mass detector, while utilizing an acoustic sampling interface for processing greater than 100,000 samples per day.
The fourth paper of this symposium, to be delivered At 3:35 pm, is from Arseniy Belov, Roland Annan, Melanie Leveridge, and Guofeng Zhang of GlaxoSmithKline; and Sammy S Datwani and Luke Ghislain of Labcyte. Their paper is titled, “Utility of a Novel Acoustic Mist Ionization Mass Spectrometry-Based Interface in Early Drug Discovery: Delivery of a Preliminary Screen.” This paper demonstrates that AMI-MS has the potential to be the next-generation interface for high-throughput screening (HTS) applications, replacing many non-MS-based technologies for early drug discovery in the future.
The final presentation of this symposium is from, Wenyi Hua and Hui Zhang of Pfizer Inc.; Sammy S Datwani, and Luke Ghislain of Labcyte; and Tom Covey and Chang Liu of Sciex, on “Label-Free High-Throughput ESI-MS Enabled by the Acoustic Droplet Ejection to the Open-Probe Probe Sampling Interface.” This 4:10 pm talk describes the coupling of acoustic droplet ejection (ADE) and a standard electrospray ionization (ESI) ion source for a mass spectrometer, with an open-port probe (OPP) sampling interface for high throughput screening (HTS); this completes a novel label-free liquid chromatography–mass spectrometry (LC–MS) system.
Emerging Trends and Challenges in Detecting Residues and Contaminants in Food in the Exposome Era
June 18th 2025This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such as LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasised.
New Research Explores Role of Nucleotide Hydrophobicity in Oligonucleotide Separation
June 18th 2025Researchers from Waters and Biospring studied the contribution of nucleotide type and modifications on the retention and resolution of 22–24 nt long oligonucleotides in different chromatographic methods.
A Life Measured in Peaks: Honoring Alan George Marshall (1944–2025)
June 18th 2025A pioneer of FT-ICR Mass Spectrometry, Alan G. Marshall (1944–2025), is best known for co-inventing Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), a transformative technique that enabled ultrahigh-resolution analysis of complex mixtures. Over a career spanning more than five decades at institutions like the University of British Columbia, The Ohio State University, and Florida State University, he published over 650 peer-reviewed papers and mentored more than 150 scientists. Marshall’s work profoundly impacted fields ranging from astrobiology to petroleomics and earned him numerous prestigious awards and fellowships. Revered for his intellect, mentorship, and dedication to science, he leaves behind a legacy that continues to shape modern mass spectrometry.