Multi-Dimensional LC for Biotherapeutic Characterization

Aqueous two-phase systems have become more popular as biomanufacturers look to adopt continuous processing. However, there are several uncertainties regarding widespread use of this technique.

LCGC International spoke to Craig Wheelock and Matthew Smith from the Wheelock Laboratory at the Karolinska Institute, Sweden, about a novel desorption electrospray ionization–multiple-reaction-monitoring mass spectrometry (DESI-MRM-MS) workflow his team has developed to spatially map oxylipins in pulmonary tissue.

Two-dimensional liquid chromatography (2D-LC) coupled to mass spectrometry (MS) has been used to separate proteins in the venom of the Indian cobra snake.

Ping Wei powder is a type of traditional Chinese medicine used to treat digestive system diseases. Its growth in popularity has led to scientists seeking to properly identify its chemical profile.