New Advancements in Biopharma Protein Characterization Using HRIM
Webinar Date/Time: Friday, September 29, 2023 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
Unlock a new realm of molecular analysis in biopharma as we delve into the MOBIE® platform's unprecedented gas-phase separation capabilities, offering superior insights into isomeric N-glycans, peptide PTMs, and intact proteins. Don't miss this opportunity to discover how the MOBIE platform empowers enhanced structural understanding, increased throughput, and greater reproducibility, revolutionizing biopharmaceuticals and more.
Register Free: https://www.chromatographyonline.com/lcgc_w/biopharma-protein
Event Overview
This seminar will demonstrate the utilization of the MOBIE® platform, a high-resolution ion mobility-mass spectrometry (HRIM-MS) instrument based on structures for lossless ion manipulation (SLIM) technology. The platform provides the highest commercially available IM resolution across the full mass range for a variety of biopharma relevant applications. This technology adds a new dimension of gas-phase separation to molecular analysis and is an orthogonal technique to existing MS workflows, which enables increased throughput, additional structural insights, and higher reproducibility. This webinar will focus on peptide therapeutic relevant applications such as:
- LC-HRIM-MS characterization of released N-Glycans.
- Isomeric/isobaric post-translational modifications (PTMs).
- Intact proteins, including mAbs, using the additional dimension of gas-phase separation.
Key Learning Objectives:
- Receive an overview of SLIM technology and the MOBIE platform.
- Learn the advantages of digital separations on throughput, resolution, and reproducibility.
- Understand the real-world impact of HRIM analysis on biotherapeutic analysis.
Who Should Attend:
- Scientists, lab directors, R&D scientists, QA/QC scientists and directors
Speaker:
Greg Kilby
Distinguished Scientist
MOBILion Systems, Inc
With a distinguished career spanning more than 15 years in biopharmaceutical research, Dr Greg Kilby has emerged as a prominent figure in the realm of molecular analysis and mass spectrometry. Holding a PhD in analytical chemistry, Greg's expertise encompasses the pioneering application and development of cutting-edge ion mobility-mass spectrometry technologies. His transformative work revolves around harnessing these innovative platforms to decipher intricate biomolecular structures, shedding light on the complexities of peptide therapeutics and biopharmaceuticals. As an advocate for scientific advancement, Greg's contributions continue to shape the landscape of biopharmaceutical analysis, consistently pushing the boundaries of knowledge and discovery.
Register Free: https://www.chromatographyonline.com/lcgc_w/biopharma-protein
TD-GC–MS and IDMS Sample Prep for CRM to Quantify Decabromodiphenyl Ether in Polystyrene Matrix
April 26th 2024At issue in this study was the certified value of decabromodiphenyl ether (BDE 209) in a polystyrene matrix CRM relative to its regulated value in the EU Restriction of Hazardous Substances Directive.
LC–MS/MS-Based System Used to Profile Ceramide Reactions to Diseases
April 26th 2024Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
