Ralph N. Adams Award

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E-Separation Solutions

Norman Dovichi, of the University of Notre Dame (South Bend, Indiana) will be presiding over this Wednesday afternoon session.

Session 1850, Room 300

Norman Dovichi, of the University of Notre Dame (South Bend, Indiana) will be presiding over this Wednesday afternoon session.

Following opening remarks by Dovichi, Penny R. Gardner, Immediate Former President of The Pittsburgh Conference, will proceed with the presentation of the 2012 Ralph N. Adams Award to Jonathan V. Sweedler, of the University of Illinois at Urbana-Champaign (Champaign, Illinois).

Sweedler will follow with a presentation of “Neurometabolomics: The Cell-by-Cell Chemical Characterizations of the Brain,” in which a suite of bioanalytical approaches are described that allow the investigation of individual neurons and small brain regions. These approaches include capillary-scale separations coupled to mass spectrometric detection, and direct mass spectrometric-based profiling and imaging.

Paul Bohn, of the University of Notre Dame (Notre Dame, Indiana), will follow with “Spatial Heterocorrelation of Confocal Raman Scattering with Secondary Ion and Laser Desorption-Ionization Mass Spectrometry,” which explores the potential of heterocorrelated mass spectrometric and confocal Raman microscopy chemical imaging, as targeted to the problem of microbial, and environmental processes.


The next presentation in the session is titled “Top Down Proteomics on a High Throughput Basis: Driving Towards High Coverage of the Endogenous Proteome” and will be delivered by Neil L. Kelleher, of Northwestern University (New York, New York). Kelleher will discuss a platform developed in his laboratory for the large scale use of multiplexed 2D separations coupled to capillary LC–LTQ–FTMS to achieve unprecedented proteome coverage.

Following a 15-minute recess, Michael L. Hein, of the University of Arizona (Tucson, Arizona), will present at talk titled “Thin Film Sensors for Zeptomole Analysis of Neurotransmitters.” Hein will describe a novel platform that encompasses thin-film–based sensors to allow for optical microscopy and electrochemical detection from single cells and individual vesicles.

Norman J. Dovichi, of the University of Notre Dame, will give the final presentation, “Diagonal Capillary Electrophoresis,” which offers a universal method to map the phosphorylation pattern of peptides. The method employs two-dimensional capillary electrophoresis with identical separation modes in each capillary.