Researchers from the University of Gothenburg and other sites in Sweden, along with researchers from Portland, Oregon and Quebec, Canada conducted a study to examine the role of serum sex steroids in fracture risk among men.
Researchers from the University of Gothenburg and other sites in Sweden, along with researchers from Portland, Ore. and Quebec, conducted a study to examine the role of serum sex steroids in fracture risk among men. The study included 2,639 men with a mean age of 75 years from MrOS Sweden, a prospective, population-based cohort. The researchers used a specific gas chromatography–mass spectrometry technique to analyze sex steroids at baseline. After baseline, the incidence of at least one fracture was 20.9 per 1,000 person-years. The researchers found an inverse relationship between fracture risk and estradiol (HR per standard deviation decrease=1.34), free estradiol (HR per SD decrease=1.41), testosterone (HR per SD decrease=1.27), and free testosterone (HR per SD decrease=1.32). However, sex hormone–binding globulin was directly related to fracture risk (HR per SD decrease=1.41), according to the researchers.
Inside the Laboratory: The Gionfriddo Group at the University at Buffalo
March 28th 2024In this edition of “Inside the Laboratory,” Emanuela Gionfriddo, PhD, an associate professor of chemistry at the University at Buffalo, discusses her group’s current research endeavors, including using solid-phase microextraction (SPME) coupled to liquid chromatography (LC) and gas chromatography (GC) to further understand the chemical relationship between environmental exposure and disease and elucidate micropollutants fate in the environment and biological systems.
Transferring Methods to Compact and Portable HPLC
February 14th 2024The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.