Intact and reduced IgGs have been successfully retained and separated using a non-porous column. Potential applications of Presto columns for a single-injection separation of free drug, antibody, and antibody-drug complexes (ADCs) is also discussed.
Nano-liquid chromatography-high-resolution tandem mass spectrometry (nano-LC-HRMS/MS) reveals saliva protein shifts before and after multiple sclerosis therapy.
Max Besenhard explains how hybrid mechanistic and machine learning models can make HPLC method development quicker, more robust and ready for autonomous digital twins.