Skin Permeability Modeling of Pharmaceutical and Cosmetic Compounds Using Retention Measurements in Liquid or Supercritical Fluid Chromatography

Author(s)Debby Mangelings, Yasmine Grooten, Yvan Vander Heyden

This article explores the use of chromatographic retention measurements in both LC and SFC to develop quantitative retention activity relationship (QRAR) models, offering a predictive tool for skin permeability without animal testing.

Oral administration of drugs may present particular disadvantages, such as a pronounced first-pass effect or adverse side effects. To avoid these problems, transdermal administration may be a good alternative. Several chromatographic systems were investigated to estimate the skin permeability of various pharmaceutical and cosmetic compounds, including reversed-phase liquid chromatography (RPLC), micellar liquid chromatography (MLC), ultrahigh-pressure liquid chromatography (UHPLC), and supercritical fluid chromatography (SFC). Fast methods were searched as an alternative for the current methods to predict the skin permeability.