This article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns.
In multivariate calibration and modelling a model is built between a large data matrix containing many variables for each sample and the property of the sample.
The various steps of an experimental design-based approach are considered and the problems that arise from wrong choices are described.
A systematic approach to developing drug impurity profiling methods.
In this Practical Data Handling column, method development for drug impurity profiling is discussed.
Part two of the column on response surface designs looks at data analysis and various approaches to simultaneously optimize multiple responses