Trends in LC–MS

New upgrades to the Waters Corporation Alliance iS HPLC System Software systems were recently discussed at HPLC 2025.

Here is some of the most-read content posted on LCGC International this week.

An innovative workflow that combines iterative data-dependent acquisition (DDA) and data-independent acquisition (DIA) to enhance the identification of unknown pollutants in urban runoff is presented.

A new separation platform based on chromatographic techniques was used to characterize algae hydrocolloids.

This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such as LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasized.

Researchers from Waters and Biospring studied the contribution of nucleotide type and modifications on the retention and resolution of 22–24 nt long oligonucleotides in different chromatographic methods.