Alberto Cavazzini has been a full professor of analytical chemistry in the Department of Chemical, Pharmaceutical, and Agricultural Sciences at the University of Ferrara since 2014. He was research fellow at the University of Tennessee, Knoxville, USA, and Oak Ridge National Laboratories, Oak Ridge in Tennessee (2000–2002), in the group of Prof. Georges Guiochon.
When van Deemter Goes Upside Down in Chiral Chromatography
May 2nd 2023The occurrence of convex-upward van Deemter curves is rare but not unusual in chiral liquid chromatography. In this work, this behaviour, experimentally observed for the more retained enantiomer of a chiral sulfoxide on a polysaccharide-based CSP, is explained.
Boosting the Purification Process of Biopharmaceuticals by Means of Continuous Chromatography
June 2nd 2020Single-column (batch) chromatography, involving two or more successive single-column (batch) chromatographic steps, is a standard approach for purifying biopharmaceuticals. Step one, known as the capture step, is used to remove product-related impurities, and step two, the polishing step, is used to remove product-related impurities. Here we present and illustrate the advantages of continuous chromatography for these separations: capture simulated moving bed (captureSMB) for the capture step and multicolumn countercurrent solvent gradient purification (MCSGP) for polishing.