Ana Butler
Articles
Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma
Mark Kester;Welley Loc;Christopher O. McGovern;Ana Butler;Peter J. Butler;Gail L. Matters;James H. Adair;Jill P. Smith;Amra Tabakovic;Bruce A. Stanley;Jenny P. Dai
October 1st 20135-Fluorouracil (5-FU) is a low-molecular-weight anticancer drug in clinical use for several solid tumors in humans. Currently, the most widely used methodology for 5-FU quantitation is liquid chromatography–tandem mass spectrometry (LC–MS-MS) with either liquid–liquid extraction (LLE), protein precipitation, or a combination of both as sample cleanup procedures.
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