Atis Chakrabarti | Authors


Detection of Protein Heterogeneity by HPLC

Protein heterogeneity is generated by post-translational modification, decomposition, and a variety of other processes, including chemical modification, denaturation, and aggregation. Since antibodies and recombinant proteins are now widely used for therapeutic treatment, it is essential to evaluate their heterogeneity during development, stability testing, and in the quality control of the final product.