BUCHI

Selecting the right LC system is a strategic decision. The right choice depends on your samples, purification goals, detection needs, throughput, workflow complexity, available lab space, and plans for future growth. BUCHI’s Liquid Chromatography Buyer’s Guide helps you evaluate these factors clearly, so you can choose your next system with confidence. Inside the guide: Five steps to identify your purification pathway Guidance on matching system capability to workflow needs Considerations for flash chromatography and prep HPLC Decision tree to help determine which system is the best fit The guide introduces two BUCHI chromatography system families: Pure Essential: designed for basic flash applications and first steps into automated chromatography. Pure Excellence: BUCHI’s flagship liquid chromatography system family for high-performance purification.

BUCHI continues to drive innovation in chromatography. To help you unlock brilliance in your lab, BUCHI launched the Pure Excellence Chromatography System, a new flash (and optional prep HPLC) instrument designed for ease of use, advanced precision, and enhanced safety. Curious to know how you can improve high-performance purifications? Join BUCHI specialists, Alina Gau and Birke Götz, as they showcase how the new Pure Excellence Chromatography System simplifies your pharma and chemistry R&D workflows.

The product portfolio includes the C-905, C-910, and C-915 for flash applications, offering flexible detection options, including ELSD. The C-950 further expands application capabilities by integrating prep HPLC, providing added versatility for laboratories with advanced purification requirements.Building on BUCHI’s long-standing reputation for reliability and innovation, the Pure Excellence Chromatography Systems combine user-friendly operation with high separation performance. Key features include: A quick-release cartridge holder enabling secure, one-handed cartridge installation to simplify daily operation. Automated and manual sample injection modes supporting both liquid injection and solid sample loading for improved reproducibility and time efficiency. A high-performance pump with a three-piston design ensures pulse-free flow. Evaporative Light Scattering Detection (ELSD) offers near-maintenance-free operation and high detection accuracy through patented direct nano-pulse injection technology. Four-solvent gradient capability expands method development flexibility and simplifies challenging separations. Advanced safety features, including continuous system monitoring, active ventilation with a closed fraction collector (enabling operation outside a fume hood), and RFID-based fraction collector rack identification. Intuitive software with method/run preview, simplified gradient editing, and always visible run monitoring supports faster, more consistent purification. With a focus on simplicity, performance, and safety, the Pure Excellence Chromatography Systems enable laboratories to achieve purification goals faster and with greater confidence.

See how the Pure Excellence Chromatography System makes purification faster, safer, and easier than ever. In this product demo, we walk through every step of running a chromatographic separation, from priming the solvent lines to collecting your final fractions.

This study investigates the separation of egg white proteins using flash and prep HPLC with silica stationary phases varying in pore and particle sizes. Larger pore sizes improved protein interaction with the stationary phase, while particles above 10 µm were ineffective. Optimal separation was achieved using the Pure Excellence C-950 with a PrepPure C18WP column, combining wide pores, small particles, and a step gradient.