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Chris Crafts | Authors
Articles
Single Calibrant Approach for the Analysis of Unknowns Using Dual Gradient Pump and Charged Aerosol Detection
Quantification of substances, such as drug impurities or library compounds when pure standards are not available is difficult yet often necessary.
Fast Analysis of Naproxen Sodium with the Acclaim Trinity P1 Column and Charged Aerosol Detection
ESA - a Dionex Company Application Note
Fast Analysis of Naproxen Sodium with the Acclaim Trinity P1 Column and Charged Aerosol Detection
The characterization of pharmaceutical salts is critical to the drug development process. Active pharmaceutical ingredient (API) salts influence the solubility, stability and hygroscopicity of pharmaceuticals and affect the final drug formulation. Traditionally, the analysis of the API and its counterion salt requires separate applications. Nanopolymer silica hybrid (NSH) technology in the Acclaim Trinity P1 column along with the Corona ultra charged aerosol detector (CAD) enables simultaneous analysis of the API and counterion over four orders of magnitude.