Gerard Rozing | Authors


HPLC Column Technology 2008 — Back to the Future?

Based upon early theoretical predictions of thought leaders in the beginnings of high performance liquid chromatography (HPLC), the continuous evolution of a reduction of particle sizes in HPLC column technology along with improvements in instrumentation has led to the increased use of particles in the sub-2-mm range, which places certain constraints on operating conditions. In this article, Gerard Rozing puts theory and practice into perspective when using small particles at increased operating pressure and, in particular, looks at thermal effects that can affect overall performance.