Itaru Yazawa

Metal-free columns should be considered when troubleshooting ion suppression. Chelating compounds that can form metal salt with stainless steel column housings are examined.

Polar neurotransmitters are difficult to retain using ODS columns. In this work we show two different methods to retain these polar analytes on the multi-mode Scherzo SS-C18 column. The versatility in retention characteristics with simple changes in mobile phase is highlighted.

The challenging retention of polar organic acids in reversed phase conditions is accomplished using a unique multi-mode stationary phase.

The Intrada Amino Acid column has been shown to be a viable solution for the analysis of amino acids by LC–MS without derivatization.

Compounds such as ibuprofen, chlorpheniramine, and allantoin are important in the field of pharmaceuticals and cosmetics. The analysis of acidic and basic compounds is particularly important but it is sometimes difficult to analyze both acidic and basic compounds on a single standard C18 column. Imtakt's Scherzo SM-C18 and Scherzo SW-C18 HPLC columns can separate acidic ibuprofen and basic chlorpheniramine simultaneously.

Simultaneous HPLC analysis of neurotransmitters can be challenging due to the similarity of their structures.

Metabolomics, the study of small molecule metabolites that are found within a biological sample, is an emerging field of study. Progress in this field depends upon technological advancement in the fields of LC–MS and separation technology.