Jingcun Wu | Authors


Rapid and Sensitive Determination of Residues of Triphenylmethane Dyes and Their Metabolites in Animal Tissues by LC–MS/MS

This method has greater sensitivity and a shorter LC analysis time than the AOAC method. It also requires less instrument maintenance, enhances column lifetime by requiring a smaller sample volume, and reduces cost by replacing acetonitrile with methanol in the mobile phase.

Analysis of 12 Regulated Mycotoxins in 8 Food Matrices by Single Immunoaffinity Cleanup and Isotope Dilution LC–MS/MS

Mycotoxins are toxic metabolites produced by fungal species often found in agricultural products. An accurate method for analyzing 12 regulated mycotoxins is described using UHPLC–MS/MS. The method demonstrated limits of quantitation (LOQs) for all analytes below stringent regulatory limits, making the method suitable for routine mycotoxin analysis.

Analysis of Tobacco-Specific Nitrosamines in Cigarette Tobacco, Cigar Tobacco, and Smokeless Tobacco by Isotope Dilution LC–MS/MS

Tobacco-specific nitrosamines are important carcinogens in tobacco products. This article describes a fast, sensitive, selective, and robust method for analysis of these compounds in various tobacco samples by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The separation of analytes from matrix interfering components was performed using a C18 column with simple LC–MS mobile phases. To minimize sample matrix effects on each analyte, a separate internal standard was used for each analyte. Two MS/MS ion pairs were used for each analyte for analyte confirmation and quantification, further enhancing the method’s selectivity and accuracy. The method was validated using different tobacco matrices.