Max Allsworth | Authors

Owlstone Medical

Max Allsworth is the Chief Science Officer at Owlstone Medical and has over 15 years’ experience in the development of trace chemical detection technologies. He has developed sensor technologies for a vast range of applications including personal safety, food contamination and environmental monitoring.


Detecting Biomarkers in Breath using GC–MS

Biomarker studies using exhaled breath are rapidly emerging as a technique for early disease detection and precision medicine. By offering a completely non-invasive experience for patients as an alternative to painful biopsy procedures. A new approach has the potential to enhance patient compliance, while making clinical workflows simpler. Exhaled breath analysis, however, requires a highly sensitive analytical technique capable of accurately measuring the broad range of volatiles present in breath. In this article, we present a proof-of-concept study to demonstrate a reliable and sensitive method to detect analytes in breath samples. Using high‑resolution accurate mass (HRAM) mass spectrometry (MS), the method validates how low- and high-abundance biomarkers can be quantified from exhaled breath.