Michel Dreux | Authors
Articles
Coupling SFC with ELSD: Study of the Parameters Ruling Response
The article investigates the ELSD response variation with supercritical carbon dioxide-based mobile phases and compares the response with HPLC.
Coupling Supercritical Fluid Chromatography with Evaporative Light Scattering Detection: A Study of the Relevant Parameters Ruling Response
The mobile-phase flow rate and the amount of modifier mixed with carbon dioxide are the main parameters affecting peak area.
Factors Affecting Sensitivity of Evaporative Light Scattering Detection
An evaporative light scattering (ELS) detector is a powerful detection tool if the solutes are less volatile than the eluent. Three main processes occur successively: nebulization, evaporation of the liquid chromatographic (LC) effluent and measurement of the light scattering by the residual particles. This leads to a non-linear calibration curve such as, A= a.m b where A is the peak area,m the sample mass and b the response coefficient measured as the slope of Log A = b>Log m + Log a.
Experimental Proofs of a Correlation Between the Coefficients for the Slope of the Response Line and the Response Factor of an ELSD
The authors describe a study that was conducted to evaluate the correlation between the slope of the response line and the response factor of an ELSD that are ordinarily regarded as independent numerical coefficients.