Caroline West | Authors


Mixed-Mode Chromatography—A Review

Mixed-mode high performance liquid chromatography (MM-HPLC) involves the combined use of two (or more) retention mechanisms in a single chromatographic system. Many original stationary phases have been proposed in recent years with promising possibilities, while applications have only started to appear in the literature. In this review, the authors discuss mixed-mode chromatography stationary phases. An overview of applications using mixed-mode chromatography is described, as well as the increased interest in mixed-mode systems for two-dimensional chromatography.

Statistics for Analysts Who Hate Statistics, Part VI: Derringer Desirability Functions

Derringer desirability functions are a great favorite of mine because they are very simple and flexible. They may be applied to a variety of problems: whenever you need to select the “best” (sample, method, operating conditions etc.) from a set. It is also a convenient way to compare apples and oranges, whenever totally unrelated features must be ranked. They were first described by Derringer and Markham1 to select polymeric materials based on varied properties.

Statistics for Analysts Who Hate Statistics, Part IV: Clustering

Part IV of this series takes a closer look at clustering. Clustering can be very useful at observing your data when the sample dimensionality is large. This is a barbarian term meaning that diversity among your samples may be wide. In that case, the space reduction provided by principal component analysis (PCA) is not always convincing, because the simplification provided by a single two-dimensional plot erases too much information. Clustering allows you to preserve more information.

Creative Catalyst

Keith Bartle, Emeritus Professor of Physical Chemistry and Visiting Professor in the Energy Centre of the University of Leeds, UK, has been a creative catalyst in a wide range of chromatographic collaborations stretching from the analysis of methane in air to printing inks. He spoke to Caroline West from the University of Orléans, in Orléans, France, about his career in chromatography and his proudest scientific achievements in separation science, including his research in supercritical fluid chromatography (SFC), gas chromatography (GC), and “the unified chromatograph”.